Brisbane, Australia

Work Type

Full Time

Closing Date

COB Friday, 1 March 2019

The Company

UniQuest is Australia’s leading university commercialising entity, managing the intellectual property of The University of Queensland, benchmarking in the top 10 percent globally for university-based technology transfer offices.  Established in 1984, UniQuest has built, commercialised and managed an extensive intellectual property portfolio.  Since 2002, UniQuest and its startup companies have raised more than A$625 million to help take UQ technologies to market. More than 100 startup companies have been created resulting from UQ’s discoveries – a milestone unsurpassed by any other Australian university.  Among others, UniQuest was responsible for commercialising the HPV vaccine Gardasil®, the image correction technology used in two-thirds of the world's MRI machines, and a potential new treatment for pain through spin-out company Spinifex Pharmaceuticals Pty Ltd – a biopharmaceutical company acquired recently in one of Australia's largest ever biotech deals.

QEDDI, the Queensland Emory Drug Discovery Initiative, a business unit of UniQuest. is a fully integrated small molecule drug discovery capability based at UQ. QEDDI's team of industry-experienced drug discovery scientists collaborate with academics to translate university research across multiple disease areas with the aim of discovering new drug candidates for commercialisation by UniQuest.

The Role

Reporting to the Director of Biology, the Principal / Senior Translational Scientist as an experienced drug discovery scientist will provide scientific and operational leadership of the Translational Biology/Pharmacology function, including cell and molecular biology and planning of preclinical in vivo disease models within QEDDI’s small molecule drug discovery programs.

Position responsibilities:

  • Take a leadership role to plan, execute and analyse in vitro and in vivo work packages in accordance with project plans for evaluating novel drug targets, screening activities from target to lead optimisation as well as mechanism of action studies and proof-of-concept studies
  • Directly support multiple projects by defining and executing the preclinical translational research to inform pivotal decision points
  • Identify new therapeutic opportunities, and select the optimal biology strategy for new programs, develop pharmacodynamic and patient stratification biomarkers to support the advancement of programs
  • Project leadership in planning experiments and data analysis, ensuring scientific excellence and industrial rigor to the projects
  • Work diligently and efficiently to meet deadlines in a fast-paced environment
  • Think strategically about drug development and drive innovative solutions to key translational challenges, contribute scientific and technical expertise to multiple project teams
  • Foster an environment for employee growth and development; mentor and coach scientists whilst ensuring compliance with agreed protocols to an industry standard
  • Manage external contract research organisation (CRO) relationships/collaborations
  • Participate in and support business development activities as required

To be successful in your application you will need to demonstrate the following:

  • PhD in an Immunology/Inflammation, Cell Biology, Cancer Biology, Neurobiology or related field with 5 years industry experience in small molecule drug discovery is essential
  • A track record of success in small biotechnology or pharmaceutical companies
  • Proven track record for scientific leadership and hands-on expertise in drug discovery/pharmacology
  • Thorough understanding and hands-on knowledge of how to plan for and execute the progression of a potential drug through the stages of drug discovery into the clinic
  • Establishment/planning of target product profiles (TPPs)
  • Management of external CROs focusing on preclinical mechanism of action studies, in vivo efficacy experiments and in vitro assays to support screening activities
  • Experience working in projects across different target classes and/or a range of therapeutic areas
  • Strong collaboration skills and excellent ability to work effectively in multidisciplinary teams both internally and externally
  • Effective organisational skills that facilitate planning, multitasking and working within timelines on multiple projects with constantly changing priorities and deadlines

This is a great opportunity to be part of an exciting drug discovery initiative that will seek to translate university-based biology into small molecule drug candidates for commercialisation, bringing value to industry, to UQ and to Australia.

Further information and to apply

To apply please go to https://barringtonjames.com/jobs/principle-translational-scientist-preclinical-to-clinical-development/

For further information please email Simon Trebilcock strebilcock@barringtonjames.com