Distributed widely throughout the body, the G protein coupled receptor, protease-activated receptor 2 (PAR2) has been implicated as a pro-inflammatory mediator in chronic inflammatory diseases including arthritis, psoriasis, inflammatory bowel disease, pancreatitis, and cardiovascular disease. PAR2 has also been reported as anti-inflammatory and protective in some conditions such as gastric ulcer and asthma. PAR2 activation has also been linked to proliferation, metastasis and angiogenesis in many cancers including cancers of the stomach, colon, breast and pancreas. In this context, small-molecule modulators of PAR2 are of potential interest as a new class of anti-inflammatory and pro-inflammatory, and/or anti-proliferative or proliferative agents.

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Stephen Earl

Director, Commercialisation – Life Sciences
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+61 421 780 689
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