Hyperglycemia is common during critical illness and is associated with increased morbidity and mortality. Development is multifactorial and involves counter-regulatory pathways in response to major injury and/or acute illness. There remains a paucity of data as to whether modified nutritional formula alters inflammation and improves major risk factors for mortality, including hyperglycemia, hypoglycemia and glycemic variability.

UQ researchers have demonstrated that provision of ‘a low carbohydrate formula’ was associated with improved glucose control seen as reduced insulin administration, attenuation of glycaemic variability and reduced mean blood glucose levels.

While the team’s current proposal is focused on critically ill patients, there are plans for extension to other disease specific areas widening the scope of application significantly.

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