Available technologies
Novel constructs for flavivirus vaccines and diagnostics
Team
Life Science
Industry
Healthcare
Sector
MedTech Programs, Therapeutic Programs
Researchers at The University of Queensland have developed a new chimeric virus platform suitable for use in flavivirus vaccine and diagnostic applications.
Key features
- Chimeras combining an insect-specific flavivirus (ISF) genomic backbone with specific antigenic elements of a vertebrate-infecting flavivirus (VIF)
- ISF chimeras replicate only in mosquito cells and are expected to be safe to administer to humans and can be prepared with minimal biocontainment
- Data shows diagnostic and vaccine applications with strong antigenic authenticity
- ISF chimeras successfully designed to display the antigens from a range of flavivirus pathogens including dengue fever and Zika.
