Over the past decade rapid advances in the methods for generating embryonic or induced pluripotent stem cells combined with cardiac differentiation protocols have led to widespread use of human cardiomyocytes as a model system. It is widely acknowledged that these cardiomyocytes exhibit immature characteristics reminiscent of embryonic stages of development. These cells therefore fail to model many attributes of adult cardiomyocytes required by researchers or industry. To overcome these issues, a novel maturation medium has been developed at The University of Queensland that allows an increased degree of human cardiomyocyte maturation to be achieved. The novel maturation medium is serum free and facilitates changes in metabolism and cell cycle that closely recapitulate changes occurring during postnatal cardiac maturation.
Status & Access
Optimised formulation and validated with extensive proof of principle studies; provisional patent application filed.
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